Platinum in Treating Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
3期
进行中(已停止招募)
NCT02445391
| 适应症 | Estrogen Receptor Negative, HER2/Neu Negative, Invasive Breast Carcinoma, Progesterone Receptor Negative |
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| 分期 | 3期 |
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| 申办方 | ECOG-ACRIN Cancer Research Group |
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| 状态 | 进行中(已停止招募) |
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| 受试者人数 | 415 人 |
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| 干预(药物) | Capecitabine, Carboplatin, Cisplatin |
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| 开始日期 | 2015年10月20日 |
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| 完成日期 | 2021年4月7日 |
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| 结果公布日 | 2022年10月5日 |
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摘要
This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether cisplatin or carboplatin is more effective than capecitabine in treating patients with residual triple negative basal-like breast cancer.
3-year Invasive Disease-Free Survival (IDFS) Rate in Basal-Subtype Patients
No mandatory timeline, assessed at any time as a standard of care procedure or at the investigator's discretion; data reported every 3 months within 2 years from randomization, every 6 months if 2-3 years. · percentage of participants
| Arm B (Cisplatin or Carboplatin) (Enrolled While Arm C Was Open) | 42.0 percentage of participants |
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| Arm C (Capecitabine) (Open to Accrual 6/22/2016) | 49.4 percentage of participants |
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| Hazard Ratio (HR) | 1.06 (95% CI 0.62–1.81) |
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。