BENITIONSClinical Trial Intelligence

Platinum in Treating Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy

3期 进行中(已停止招募) NCT02445391

适应症Estrogen Receptor Negative, HER2/Neu Negative, Invasive Breast Carcinoma, Progesterone Receptor Negative
分期3期
申办方ECOG-ACRIN Cancer Research Group
状态进行中(已停止招募)
受试者人数415 人
干预(药物)Capecitabine, Carboplatin, Cisplatin
开始日期2015年10月20日
完成日期2021年4月7日
结果公布日2022年10月5日

摘要

This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether cisplatin or carboplatin is more effective than capecitabine in treating patients with residual triple negative basal-like breast cancer.

3-year Invasive Disease-Free Survival (IDFS) Rate in Basal-Subtype Patients

No mandatory timeline, assessed at any time as a standard of care procedure or at the investigator's discretion; data reported every 3 months within 2 years from randomization, every 6 months if 2-3 years. · percentage of participants

Arm B (Cisplatin or Carboplatin) (Enrolled While Arm C Was Open)42.0 percentage of participants
Arm C (Capecitabine) (Open to Accrual 6/22/2016)49.4 percentage of participants
Hazard Ratio (HR)1.06 (95% CI 0.62–1.81)

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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。