Platinum in Treating Patients With Residual Triple-Negative Breast Cancer Following Neoadjuvant Chemotherapy
第3相
実施中(募集終了)
NCT02445391
| 対象疾患 | Estrogen Receptor Negative, HER2/Neu Negative, Invasive Breast Carcinoma, Progesterone Receptor Negative |
|---|
| 相 | 第3相 |
|---|
| スポンサー | ECOG-ACRIN Cancer Research Group |
|---|
| ステータス | 実施中(募集終了) |
|---|
| 参加者数 | 415 名 |
|---|
| 介入(薬剤) | Capecitabine, Carboplatin, Cisplatin |
|---|
| 開始日 | 2015年10月20日 |
|---|
| 完了日 | 2021年4月7日 |
|---|
| 結果公開日 | 2022年10月5日 |
|---|
概要
This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether cisplatin or carboplatin is more effective than capecitabine in treating patients with residual triple negative basal-like breast cancer.
3-year Invasive Disease-Free Survival (IDFS) Rate in Basal-Subtype Patients
No mandatory timeline, assessed at any time as a standard of care procedure or at the investigator's discretion; data reported every 3 months within 2 years from randomization, every 6 months if 2-3 years. · percentage of participants
| Arm B (Cisplatin or Carboplatin) (Enrolled While Arm C Was Open) | 42.0 percentage of participants |
|---|
| Arm C (Capecitabine) (Open to Accrual 6/22/2016) | 49.4 percentage of participants |
|---|
| Hazard Ratio (HR) | 1.06 (95% CI 0.62–1.81) |
BENITIONS で見る
ClinicalTrials.gov の原文を見る
同じ疾患の他の治験
すべての治験
このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。