Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps
2期
进行中(已停止招募)
NCT02134925
| 适应症 | Colorectal Adenoma, Colorectal Carcinoma, Colorectal Conventional Adenoma With Severe Dysplasia, Colorectal Tubulovillous Adenoma |
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| 分期 | 2期 |
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| 申办方 | National Cancer Institute (NCI) |
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| 状态 | 进行中(已停止招募) |
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| 受试者人数 | 110 人 |
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| 干预(药物) | Laboratory Biomarker Analysis, MUC1 Peptide-Poly-ICLC Vaccine, Quality-of-Life Assessment, Saline |
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| 开始日期 | 2014年6月23日 |
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| 完成日期 | 2017年1月27日 |
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| 结果公布日 | 2018年5月18日 |
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摘要
This randomized phase II clinical trial studies how well MUC1 peptide-poly-ICLC adjuvant vaccine works in treating patients with newly diagnosed advanced colon polyps (adenomatous polyps). Adenomatous polyps are growths in the colon that may develop into colorectal cancer over time. Vaccines made from peptides may help the body build an effective immune response to kill polyp cells. MUC1 peptide-poly-ICLC adjuvant vaccine may also prevent the recurrence of adenomatous polyps and may prevent the development of colorectal cancer.
Change in Anti-MUC1 Immunoglobulin G (IgG) Levels as Determined by Enzyme-linked Immunosorbent Assay (ELISA)
Week 0 to week 12 · IgG ratio
| Arm I (MUC1 Peptide-poly-ICLC Adjuvant Vaccine) | 1.2 IgG ratio |
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| Arm II (Placebo) | 1.0 IgG ratio |
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本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。