BENITIONSClinical Trial Intelligence

Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps

2期 进行中(已停止招募) NCT02134925

适应症Colorectal Adenoma, Colorectal Carcinoma, Colorectal Conventional Adenoma With Severe Dysplasia, Colorectal Tubulovillous Adenoma
分期2期
申办方National Cancer Institute (NCI)
状态进行中(已停止招募)
受试者人数110 人
干预(药物)Laboratory Biomarker Analysis, MUC1 Peptide-Poly-ICLC Vaccine, Quality-of-Life Assessment, Saline
开始日期2014年6月23日
完成日期2017年1月27日
结果公布日2018年5月18日

摘要

This randomized phase II clinical trial studies how well MUC1 peptide-poly-ICLC adjuvant vaccine works in treating patients with newly diagnosed advanced colon polyps (adenomatous polyps). Adenomatous polyps are growths in the colon that may develop into colorectal cancer over time. Vaccines made from peptides may help the body build an effective immune response to kill polyp cells. MUC1 peptide-poly-ICLC adjuvant vaccine may also prevent the recurrence of adenomatous polyps and may prevent the development of colorectal cancer.

Change in Anti-MUC1 Immunoglobulin G (IgG) Levels as Determined by Enzyme-linked Immunosorbent Assay (ELISA)

Week 0 to week 12 · IgG ratio

Arm I (MUC1 Peptide-poly-ICLC Adjuvant Vaccine)1.2 IgG ratio
Arm II (Placebo)1.0 IgG ratio
p-value0.0004

在 BENITIONS 中查看 查看 ClinicalTrials.gov 原文

同一适应症的其他试验

全部试验

本页整理自 ClinicalTrials.gov 的公开数据,不构成医疗建议,也不构成投资建议。请务必咨询专业医师。