BENITIONSClinical Trial Intelligence

Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps

第2相 実施中(募集終了) NCT02134925

対象疾患Colorectal Adenoma, Colorectal Carcinoma, Colorectal Conventional Adenoma With Severe Dysplasia, Colorectal Tubulovillous Adenoma
第2相
スポンサーNational Cancer Institute (NCI)
ステータス実施中(募集終了)
参加者数110 名
介入(薬剤)Laboratory Biomarker Analysis, MUC1 Peptide-Poly-ICLC Vaccine, Quality-of-Life Assessment, Saline
開始日2014年6月23日
完了日2017年1月27日
結果公開日2018年5月18日

概要

This randomized phase II clinical trial studies how well MUC1 peptide-poly-ICLC adjuvant vaccine works in treating patients with newly diagnosed advanced colon polyps (adenomatous polyps). Adenomatous polyps are growths in the colon that may develop into colorectal cancer over time. Vaccines made from peptides may help the body build an effective immune response to kill polyp cells. MUC1 peptide-poly-ICLC adjuvant vaccine may also prevent the recurrence of adenomatous polyps and may prevent the development of colorectal cancer.

Change in Anti-MUC1 Immunoglobulin G (IgG) Levels as Determined by Enzyme-linked Immunosorbent Assay (ELISA)

Week 0 to week 12 · IgG ratio

Arm I (MUC1 Peptide-poly-ICLC Adjuvant Vaccine)1.2 IgG ratio
Arm II (Placebo)1.0 IgG ratio
p-value0.0004

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このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。