BENITIONSClinical Trial Intelligence

Study of mRNA-1010 Seasonal Influenza Vaccine in Adults

Phase 3 Completed NCT05827978

ConditionSeasonal Influenza
PhasePhase 3
SponsorModernaTX, Inc.
StatusCompleted
Enrollment8,411 participants
InterventionsmRNA-1010, Licensed Quadrivalent Inactivated Seasonal Influenza Vaccine
Start dateApr 17, 2023
Completion dateJun 24, 2024
Results postedJul 10, 2025

Summary

This study includes 3 parts: Parts A, B, and C. The purpose of this study is to evaluate the immunogenicity and safety of mRNA-1010 seasonal influenza vaccine in adults.

Geometric Mean Titer (GMT) of Anti-Hemagglutinin (HA) Antibody Levels as Measured by Hemagglutination Inhibition (HAI)

Day 29 · titer

Part A: Fluarix QIV147.49 titer
Part A: mRNA-1010220.17 titer
Part B: Fluarix QIV137.90 titer
Part B: mRNA-1010208.10 titer
Part C: Fluzone HD QIV130.09 titer
Part C: mRNA-1010174.81 titer

Percentage of Participants Reaching Seroconversion, as Measured by HAI

Day 29 · percentage of participants

Part A: Fluarix QIV34.9 percentage of participants
Part A: mRNA-101050.2 percentage of participants
Part B: Fluarix QIV45.0 percentage of participants
Part B: mRNA-101064.4 percentage of participants
Part C: Fluzone HD QIV36.3 percentage of participants
Part C: mRNA-101049.7 percentage of participants

Number of Participants With Solicited Local and Systemic Adverse Reactions (ARs)

Up to 7 days after study injection · Participants

Part A: Fluarix QIV682 Participants
Part A: mRNA-10101060 Participants
Part B: Fluarix QIV796 Participants
Part B: mRNA-10101158 Participants
Part C: Fluzone HD QIV734 Participants
Part C: mRNA-10101131 Participants

Open in BENITIONS View on ClinicalTrials.gov

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This page summarises publicly available data from ClinicalTrials.gov. It is not medical advice and not investment advice. Always consult a qualified healthcare professional.