Guselkumab in Active Psoriatic Arthritis Participants With Inadequate Response/Intolerance to One Prior Anti-TNF Alpha Agent
| Condition | Arthritis, Psoriatic |
|---|---|
| Phase | Phase 3 |
| Sponsor | Janssen Research & Development, LLC |
| Status | Active, not recruiting |
| Enrollment | 453 participants |
| Interventions | Guselkumab |
| Start date | Sep 28, 2021 |
| Completion date | Oct 28, 2024 |
| Results posted | Dec 8, 2025 |
Summary
The purpose of this study is to evaluate the efficacy of guselkumab treatment in participants with active psoriatic arthritis (PsA) and inadequate response (IR) and/or intolerance to a prior anti-tumor necrosis factor (TNF) by assessing the reduction in signs and symptoms of PsA.
Percentage of Participants Who Achieved an American College of Rheumatology (ACR) 20 Response at Week 24
| Placebo Followed by Guselkumab 100 mg | 35.9 Percentage of participants |
|---|---|
| Guselkumab 100 mg q8w | 63.0 Percentage of participants |
| Guselkumab 100 mg q4w | 60.9 Percentage of participants |
Open in BENITIONS View on ClinicalTrials.gov
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- A Study to Assess the Pharmacokinetics, Safety, and Efficacy of Two Doses of Bimekizumab i — UCB Biopharma SRL
- A Study of JNJ-77242113 for the Treatment of Participants With Generalized Pustular Psoria — Janssen Pharmaceutical K.K.
- A Study of Guselkumab and Golimumab Combination Therapy in Participants With Active Psoria — Janssen Research & Development, LLC
- A Study to Evaluate the Efficacy and Safety of Bimekizumab in the Treatment of Subjects Wi — UCB Biopharma SRL
- A Study to Test the Efficacy and Safety of Bimekizumab in the Treatment of Subjects With A — UCB Biopharma SRL
- The Efficacy and Safety of TLL018 in Moderate-to-severe Plaque Psoriasis — Hangzhou Highlightll Pharmaceutical Co., Ltd