BENITIONSClinical Trial Intelligence

Clinical Trial of YH25448(Lazertinib) as the First-line Treatment in Patients With EGFR Mutation Positive Locally Advanced or Metastatic NSCLC (LASER301)

Фаза 3 Завершено NCT04248829

ЗаболеваниеNon-Small Cell Lung Cancer
ФазаФаза 3
СпонсорYuhan Corporation
СтатусЗавершено
Участники393 участн.
ВмешательствоLazertinib 240 mg/160 mg, Gefitinib 250 mg, Lazertinib-matching placebo 240 mg/160 mg, Gefitinib-matching placebo 250 mg
Дата начала13.02.2020
Дата завершения29.07.2022
Публикация результатов22.03.2024

Кратко

This Phase III study will be conducted to evaluate the efficacy and safety of YH25448 as first-line treatment in locally advanced or metastatic Non-small Cell Lung Cancer (NSCLC) patients with EGFR mutations

Progression-Free Survival (PFS) According to RECIST v1.1 by Investigator Assessment

At baseline and every 6 weeks for the first 18 months and then every 12 weeks relative to randomization until progression, assessed up to 29 months per participant. · Months

Lazertinib 240 mg20.6 Months
Gefitnib 250 mg9.7 Months

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