BENITIONSClinical Trial Intelligence

Evaluation of Upadacitinib in Adolescent and Adult Patients With Moderate to Severe Atopic Dermatitis (Eczema)

Фаза 3 Завершено NCT03569293

ЗаболеваниеAtopic Dermatitis
ФазаФаза 3
СпонсорAbbVie
СтатусЗавершено
Участники912 участн.
ВмешательствоPlacebo for Upadacitinib, Upadacitinib
Дата начала13.08.2018
Дата завершения6.01.2021
Публикация результатов3.02.2022

Кратко

The objective of this study is to assess the efficacy and safety of upadacitinib for the treatment of adolescent and adult participants with moderate to severe atopic dermatitis (AD) who are candidates for systemic therapy.

Main Study: Percentage of Participants Achieving at Least a 75% Reduction in Eczema Area and Severity Index Score (EASI 75) From Baseline at Week 16

Baseline and Week 16 · percentage of participants

Placebo16.3 percentage of participants
Upadacitinib 15 mg QD69.6 percentage of participants
Upadacitinib 30 mg QD79.7 percentage of participants
p-value<0.001
Adjusted Response Rate Difference63.4 (95% CI 57.1–69.8)

Main Study: Percentage of Participants Achieving Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD) of 0 or 1 With a Reduction From Baseline of ≥ 2 Points at Week 16

Baseline and Week 16 · percentage of participants

Placebo8.4 percentage of participants
Upadacitinib 15 mg QD48.1 percentage of participants
Upadacitinib 30 mg QD62.0 percentage of participants
p-value<0.001
Adjusted Response Rate Difference53.6 (95% CI 47.2–60.0)

Открыть в BENITIONS Открыть на ClinicalTrials.gov

Другие исследования по этому заболеванию

Все исследования

Страница обобщает открытые данные ClinicalTrials.gov. Это не медицинская и не инвестиционная рекомендация. Обратитесь к врачу.