A Research Study to See How Switching From a Daily Basal Insulin to a New Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine in Adults With Type 2 Diabetes
3상
완료
NCT06340854
| 대상 질환 | Diabetes, Type 2 |
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| 임상 단계 | 3상 |
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| 스폰서 | Novo Nordisk A/S |
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| 상태 | 완료 |
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| 참여자 수 | 412 명 |
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| 중재(약물) | Insulin icodec, Insulin glargine |
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| 시작일 | 2024년 4월 19일 |
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| 완료일 | 2025년 5월 8일 |
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| 결과 공개일 | 2026년 7월 2일 |
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요약
This study compares insulin icodec, a new insulin taken once a week, to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 2 diabetes. Participants will either get insulin icodec or insulin glargine. Which treatment participants get is decided by chance. Insulin icodec is the new medicine being tested, while insulin glargine is already approved and can be prescribed by doctors. Participants will get one injection of insulin icodec once a week, or one injection of insulin glargine once a day, depending on the treatment group participants are assigned into. Participants will use a pen with a small needle to inject the medicine under participants skin into participants thigh, upper arm or stomach.The study will last for about 9 months, but participants will only be taking the study medicine for 6 months.
Change in Glycated Haemoglobin (HbA1c)
Week 0, Week 26 · Percentage (%) point
| Insulin Icodec | -0.84 ± 0.83 Percentage (%) point |
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| Insulin Glargine | -0.58 ± 0.89 Percentage (%) point |
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| p-value | <0.0001 |
| Treatment difference | -0.21 (95% CI -0.36–-0.07) |
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