BENITIONSClinical Trial Intelligence

A Research Study to See How Switching From a Daily Basal Insulin to a New Weekly Insulin, Insulin Icodec, Helps in Reducing the Blood Sugar Compared to Daily Insulin Glargine in Adults With Type 2 Diabetes

第3相 完了 NCT06340854

対象疾患Diabetes, Type 2
第3相
スポンサーNovo Nordisk A/S
ステータス完了
参加者数412 名
介入(薬剤)Insulin icodec, Insulin glargine
開始日2024年4月19日
完了日2025年5月8日
結果公開日2026年7月2日

概要

This study compares insulin icodec, a new insulin taken once a week, to insulin glargine, an insulin taken once a day. The study medicine will be investigated in participants with type 2 diabetes. Participants will either get insulin icodec or insulin glargine. Which treatment participants get is decided by chance. Insulin icodec is the new medicine being tested, while insulin glargine is already approved and can be prescribed by doctors. Participants will get one injection of insulin icodec once a week, or one injection of insulin glargine once a day, depending on the treatment group participants are assigned into. Participants will use a pen with a small needle to inject the medicine under participants skin into participants thigh, upper arm or stomach.The study will last for about 9 months, but participants will only be taking the study medicine for 6 months.

Change in Glycated Haemoglobin (HbA1c)

Week 0, Week 26 · Percentage (%) point

Insulin Icodec-0.84 ± 0.83 Percentage (%) point
Insulin Glargine-0.58 ± 0.89 Percentage (%) point
p-value<0.0001
Treatment difference-0.21 (95% CI -0.36–-0.07)

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