Effects of Administration of SCFA in Rheumatoid Arthritis Inadequate Responders

단계 해당 없음 완료 NCT05718583

요약

This study is a pilot, proof of concept study to determine the effects of administering an oral short-chain fatty acid (SCFA) supplement to Rheumatoid Arthritis (RA) patients with inadequate response to methotrexate (MTX). The study will include up to 35 participants to obtain a sample size of at least 25 participants taking the oral supplement. The researchers hypothesize that oral SCFA will change the participants' gut microbiome and regulatory immune responses. Clinical data to assess for adverse events, stool, urine samples and peripheral blood will be collected at baseline, 1 month, and with an optional 2 month time-point. Fecal microbiome will be analyzed. Adaptive immune responses will be analyzed from participant blood samples.

Change From Baseline in Microbiome Alpha Diversity

Baseline, Month 1 Post-Treatment Initiation · index

BENITIONS에서 보기 ClinicalTrials.gov 원문 보기

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