BENITIONSClinical Trial Intelligence

Predicting SSRI Efficacy in Veterans With PTSD

4상 조기 종료 NCT04183205

대상 질환Posttraumatic Stress Disorder, Major Depressive Disorder
임상 단계4상
스폰서VA Office of Research and Development
상태조기 종료
참여자 수19 명
중재(약물)LDAEP, sertraline
시작일2019년 9월 11일
완료일2025년 3월 30일
결과 공개일2026년 5월 22일

요약

This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) or depression are most likely to show a positive response to selective serotonin reuptake inhibitor (SSRI) medications. Participants will be recruited over approximately 5.25 years, until at least 94 participants complete the 17 week study.

Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) After 14 Weeks of the Medication Trial Predicted by Pretreatment LDAEP Slope (Calculated With P200 at the PZ Site) and Controlling for Baseline CAPS Score

CAPS score administered 14 weeks after starting the medication trial, controlling for baseline CAPS score · Scores on a scale

Sertraline Arm10.8 ± 9.95 Scores on a scale
p-value.08
Slope3.13

Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) After 14 Weeks of the Medication Trial as Predicted by Pretreatment LDAEP Slope (Calculated With P200 at the CZ Site) and Controlling for Baseline CAPS Score

CAPS score administered 14 weeks after starting the medication trial, controlling for baseline CAPS score · Scores on a scale

Sertraline Arm10.8 ± 9.95 Scores on a scale
p-value.01
Slope3.59

Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) After 14 Weeks of the Medication Trial as Predicted by Pretreatment LDAEP Slope (Calculated With P200 at the FZ Site) and Controlling for Baseline CAPS Score

CAPS score administered 14 weeks after starting the medication trial, controlling for baseline CAPS score · Scores on a scale

Sertraline Arm10.8 ± 25.7 Scores on a scale
p-value.24
Slope2.24

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