BENITIONSClinical Trial Intelligence

Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

第3相 実施中(募集終了) NCT03375320

対象疾患Functioning Pancreatic Neuroendocrine Tumor, Intermediate Grade Lung Neuroendocrine Neoplasm, Locally Advanced Digestive System Neuroendocrine Neoplasm, Locally Advanced Digestive System Neuroendocrine Tumor G1
第3相
スポンサーNational Cancer Institute (NCI)
ステータス実施中(募集終了)
参加者数298 名
介入(薬剤)Biospecimen Collection, Cabozantinib S-malate, Computed Tomography, Magnetic Resonance Imaging, Placebo Administration
開始日2018年10月26日
完了日2023年8月23日
結果公開日2024年10月16日

概要

This phase III trial studies cabozantinib to see how well it works compared with placebo in treating patients with neuroendocrine or carcinoid tumors that may have spread from where it first started to nearby tissue, lymph nodes, or distant parts of the body (advanced). Cabozantinib is a chemotherapy drug known as a tyrosine kinase inhibitor, and it targets specific tyrosine kinase receptors, that when blocked, may slow tumor growth.

Progression-free Survival (PFS)

36 months · months

Arm Ia (Cabozantinib S-malate, Extra-pancreatic NET Cohort [epNET])8.4 months
Arm IIa (Placebo, Extra-pancreatic NET Cohort [epNET])3.9 months
Arm Ib (Cabozantinib S-malate, Pancreatic NET Cohort [pNET])13.8 months
Arm IIb (Placebo, Pancreatic NET Cohort [pNET])4.4 months
p-value<0.0001

BENITIONS で見る ClinicalTrials.gov の原文を見る

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このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。