BENITIONSClinical Trial Intelligence

A Study of JNJ-77242113 for the Treatment of Participants With Moderate to Severe Plaque Psoriasis

第3相 実施中(募集終了) NCT06143878

対象疾患Plaque Psoriasis
第3相
スポンサーJanssen Research & Development, LLC
ステータス実施中(募集終了)
参加者数774 名
介入(薬剤)JNJ-77242113, JNJ-77242113 Matching Placebo, Deucravacitinib, Deucravacitinib Matching Placebo
開始日2024年2月1日
完了日2024年9月17日
結果公開日2026年6月25日

概要

The purpose of the study is to see how effective JNJ-77242113 is in participants with moderate to severe plaque psoriasis compared to placebo and deucravacitinib.

Percentage of Participants Who Achieved an Investigator's Global Assessment (IGA) Score of 0 or 1 and a Greater Than or Equal to (>=) 2-Grade Improvement From Baseline at Week 16

Week 16 · Percentage of participants

Arm 1: Placebo Followed by JNJ-77242113 200 mg10.9 Percentage of participants
Arm 2: JNJ-77242113 200 mg68.5 Percentage of participants
p-value<0.001
Treatment difference57.6 (95% CI 49.9–64.2)

Percentage of Participants Who Achieved Psoriasis Area and Severity Index (PASI) 90 at Week 16

Week 16 · Percentage of participants

Arm 1: Placebo Followed by JNJ-77242113 200 mg3.8 Percentage of participants
Arm 2: JNJ-77242113 200 mg55.0 Percentage of participants
p-value<0.001
Treatment difference51.2 (95% CI 44.5–57.3)

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