BENITIONSClinical Trial Intelligence

Selpercatinib for the Treatment of Advanced Solid Tumors, Lymphomas, or Histiocytic Disorders With Activating RET Gene Alterations, a Pediatric MATCH Treatment Trial

第2相 実施中(募集終了) NCT04320888

対象疾患Hematopoietic and Lymphatic System Neoplasm, Recurrent Ependymoma, Recurrent Ewing Sarcoma, Recurrent Hepatoblastoma
第2相
スポンサーNational Cancer Institute (NCI)
ステータス実施中(募集終了)
参加者数1 名
介入(薬剤)Computed Tomography, Magnetic Resonance Imaging, Positron Emission Tomography, Radionuclide Imaging, Selpercatinib
開始日2021年5月3日
完了日2024年9月30日
結果公開日2025年11月6日

概要

This phase II pediatric MATCH treatment trial studies how well selpercatinib works in treating patients with solid tumors that may have spread from where they first started to nearby tissue, lymph nodes, or distant parts of the body (advanced), lymphomas, or histiocytic disorders that have activating RET gene alterations. Selpercatinib may block the growth of cancer cells that have specific genetic changes in an important signaling pathway (called the RET pathway) and may reduce tumor size.

Objective Response Rate (Complete Response + Partial Response) in Pediatric Patients Treated With Selpercatinib (LOXO-292)

Up to 2 years from study entry · percentage of participants

Treatment (Selpercatinib)100 percentage of participants

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