BENITIONSClinical Trial Intelligence

A Study of LY3885125 in Participants With Dyslipidemia or Non-Alcoholic Fatty Liver Disease (NAFLD)

Phase 1 Terminated NCT06007651

ConditionDyslipidemias, Non-Alcoholic Fatty Liver Disease
PhasePhase 1
SponsorEli Lilly and Company
StatusTerminated
Enrollment49 participants
InterventionsLY3885125
Start dateAug 10, 2023
Completion dateFeb 12, 2025
Results postedApr 13, 2026

Summary

The main purpose of this study is to evaluate the safety and tolerability of LY3885125 after administration of single ascending doses in participants with dyslipidemia (part A) and multiple doses in participants with non-alcoholic fatty liver disease (part B). Blood tests will be performed to check how much LY3885125 gets into the bloodstream and how long it takes the body to eliminate it. The study will last up to approximately 49 weeks for part A and 62 weeks for part B, for a total of approximately 111 weeks.

Part A: Number of Participants With One or More Serious Adverse Event(s) Considered by the Investigator to be Related to Study Drug Administration

Baseline up to 36 weeks (Part A) · Participants

Part A: SAD Cohort 10 Participants
Part A: SAD Cohort 20 Participants
Part A: SAD Cohort 30 Participants
Part A: SAD Cohort 40 Participants
Part A: SAD Cohort 50 Participants
Part A: Placebo0 Participants

Part B: Number of Participants With One or More SAEs Considered by the Investigator to be Related to Study Drug Administration

Baseline up to 36 weeks (Part B)

Open in BENITIONS View on ClinicalTrials.gov

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