BENITIONSClinical Trial Intelligence

Examining Changes in Nasal IL-1 During Acute Asthma Exacerbation in Adolescents

N/A Completed NCT04748055

ConditionAsthma
PhaseN/A
SponsorUniversity of North Carolina, Chapel Hill
StatusCompleted
Enrollment40 participants
Start dateJul 27, 2021
Completion dateFeb 8, 2024
Results postedJun 29, 2026

Summary

To study the change from baseline in IL-1β (interleukin 1 beta) concentrations in the nasal airway during acute asthma exacerbation, specifically to measure the degree of change and identify the timing of peak IL-1β concentration. This information will allow the investigators to estimate effect size and guide decisions about the optimal timing of anakinra administration for the future study.

Percentage Change From Baseline in Nasal IL-1β (pg/mL) Concentrations During Asthma Exacerbation

Baseline and up to 5 days from the time asthma exacerbation is diagnosed (Months 1-12) · percentage change from baseline

All Participants171.4 percentage change from baseline

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