BENITIONSClinical Trial Intelligence

Oral Sodium to Preserve Renal EfficiencY in Acute Heart Failure

N/A Active, not recruiting NCT04334668

ConditionVolume Overload
PhaseN/A
SponsorThe Cleveland Clinic
StatusActive, not recruiting
Enrollment67 participants
InterventionsOral Sodium Chloride
Start dateMay 20, 2020
Completion dateJun 1, 2022
Results postedMar 12, 2024

Summary

The investigators are proposing a prospective, randomized, double blinded, placebo-controlled single center study evaluating the role of co-administration of oral sodium chloride (NaCl) with intravenous diuretics in patients hospitalized with acute decompensated heart failure. The investigators are approaching this study with the hypothesis that the use of oral sodium chloride leads to improved effective diuresis (as measured by weight loss) and renal function as compared to placebo in patients hospitalized with acute decompensated heart failure undergoing aggressive intravenous diuretic therapy.

Change in Weight

Baseline to 96 hours · Kilograms

Oral Sodium Chloride-3.9 ± 4.3 Kilograms
Placebo-4.6 ± 4.2 Kilograms

Change in Creatinine

Baseline to 96 hours · mEq/L

Oral Sodium Chloride0.038 ± 0.39 mEq/L
Placebo0.15 ± 0.44 mEq/L

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