BENITIONSClinical Trial Intelligence

A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer

Phase 1/2 Active, not recruiting NCT03742102

ConditionTriple Negative Breast Neoplasms
PhasePhase 1/2
SponsorAstraZeneca
StatusActive, not recruiting
Enrollment243 participants
InterventionsDurvalumab, Capivasertib, Oleclumab, Paclitaxel, Trastuzumab deruxtecan
Start dateDec 21, 2018
Completion dateNov 29, 2024
Results postedFeb 2, 2026

Summary

This study is designed to determine the efficacy and safety of durvalumab in combination with novel oncology therapies with or without paclitaxel and durvalumab + paclitaxel for first-line metastatic triple negative breast cancer

Dose Limiting Toxicity (DLT) Events

From the time of first dose until completion of the first cycle (28 days for Arms 2-5, 21 days for Arms 6-7 (no safety run-in for Arms 1 and 8)) · Participants

Arm 20 Participants
Arm 50 Participants
Arm 60 Participants
Arm 70 Participants

Open in BENITIONS View on ClinicalTrials.gov

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