A Study of Novel Anti-cancer Agents in Patients With Metastatic Triple Negative Breast Cancer
| Condition | Triple Negative Breast Neoplasms |
|---|---|
| Phase | Phase 1/2 |
| Sponsor | AstraZeneca |
| Status | Active, not recruiting |
| Enrollment | 243 participants |
| Interventions | Durvalumab, Capivasertib, Oleclumab, Paclitaxel, Trastuzumab deruxtecan |
| Start date | Dec 21, 2018 |
| Completion date | Nov 29, 2024 |
| Results posted | Feb 2, 2026 |
Summary
This study is designed to determine the efficacy and safety of durvalumab in combination with novel oncology therapies with or without paclitaxel and durvalumab + paclitaxel for first-line metastatic triple negative breast cancer
Dose Limiting Toxicity (DLT) Events
| Arm 2 | 0 Participants |
|---|---|
| Arm 5 | 0 Participants |
| Arm 6 | 0 Participants |
| Arm 7 | 0 Participants |
Open in BENITIONS View on ClinicalTrials.gov
Other trials for this condition
- Vitamin D and Physical Activity on Bone Health — University of Rochester
- Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in T — National Cancer Institute (NCI)
- Exemestane With or Without Entinostat in Treating Patients With Recurrent Hormone Receptor — National Cancer Institute (NCI)
- Tamoxifen Citrate or Z-Endoxifen Hydrochloride in Treating Patients With Locally Advanced — National Cancer Institute (NCI)
- Understanding and Addressing Rejection of Personalized Breast Cancer Risk Information: Adm — University of Colorado, Denver
- Testing the Addition of Copanlisib to Eribulin in Metastatic Triple Negative Breast Cancer — National Cancer Institute (NCI)