BENITIONSClinical Trial Intelligence

Sleep and Circadian Mechanisms of Non-dipping Blood Pressure

N/A Completed NCT03558893

ConditionHypertension, Cardiovascular Risk Factor
PhaseN/A
SponsorOregon Health and Science University
StatusCompleted
Enrollment30 participants
InterventionsForced Desynchrony
Start dateDec 1, 2018
Completion dateDec 31, 2024
Results postedJun 16, 2026

Summary

This study will be the first to distinguish the relative contributions of sleep, circadian and behavioral mechanisms to the non-dipping BP profile in Black adults and will lay the groundwork for optimizing therapies dependent on mechanisms, such as targeting sleep, targeting circadian rhythmicity, or targeting behaviors, and raising the possibility that ideal therapy for hypertension (HTN) may differ by race. This research will ultimately help to improve health and survival in black populations with HTN.

Nighttime Systolic Blood Pressure

Baseline Night Average · mmHg

White Adults101.6 ± 2.1 mmHg
Black Adults92.4 ± 4.0 mmHg

Nighttime Diastolic Blood Pressure

Baseline Night Average · mmHg

White Adults60.5 ± 1.4 mmHg
Black Adults59.0 ± 1.4 mmHg

Daytime Systolic Blood Pressure

Baseline Daytime Average · mmHg

White Adults116.6 ± 8.6 mmHg
Black Adults120.5 ± 9.7 mmHg

Open in BENITIONS View on ClinicalTrials.gov

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