A Study of Tobemstomig Plus Platinum-Based Chemotherapy vs Pembrolizumab Plus Platinum-Based Chemotherapy in Participants With Previously Untreated Non-Small Cell Lung Cancer
Фаза 2
Завершено
NCT05775289
| Заболевание | Non-small Cell Lung Cancer |
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| Фаза | Фаза 2 |
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| Спонсор | Hoffmann-La Roche |
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| Статус | Завершено |
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| Участники | 182 участн. |
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| Вмешательство | Tobemstomig, Pembrolizumab, Paclitaxel, Pemetrexed, Carboplatin |
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| Дата начала | 15.03.2023 |
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| Дата завершения | 20.06.2024 |
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| Публикация результатов | 19.11.2025 |
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Кратко
The purpose of this study is to evaluate the efficacy, safety, and pharmacokinetics of tobemstomig (RO7247669) in combination with platinum-based chemotherapy compared with pembrolizumab plus platinum-based chemotherapy in participants with previously untreated, locally advanced, unresectable (Stage IIIB/IIIC) or metastatic (Stage IV) non-small-cell lung cancer (NSCLC) who are not eligible to receive curative surgery and/or definitive chemoradiotherapy.
Progression-Free Survival (PFS)
Randomization to date of first documented disease progression or death (up to approximately 15 months) · Months
| Pembro + Chemotherapy | 7.13 Months |
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| Tobe + Chemotherapy | 7.62 Months |
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| p-value | 0.9705 |
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| Hazard Ratio (HR) | 0.99 (95% CI 0.63–1.56) |
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Objective Response Rate (ORR)
Up to approximately 15 months · Percent of participants
| Pembro + Chemotherapy | 46.2 Percent of participants |
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| Tobe + Chemotherapy | 41.1 Percent of participants |
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| p-value | 0.4056 |
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| Odds Ratio (OR) | 0.77 (95% CI 0.42–1.43) |
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