BENITIONSClinical Trial Intelligence

Combination Chemotherapy and Inotuzumab Ozogamicin in Treating Patients With B Acute Lymphoblastic Leukemia

Фаза 2 Прекращено NCT03488225

ЗаболеваниеAcute Lymphoblastic Leukemia in Remission, B Acute Lymphoblastic Leukemia, B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
ФазаФаза 2
СпонсорM.D. Anderson Cancer Center
СтатусПрекращено
Участники4 участн.
ВмешательствоCyclophosphamide, Cytarabine, Dexamethasone, Doxorubicin Hydrochloride, Inotuzumab Ozogamicin
Дата начала28.03.2018
Дата завершения2.04.2020
Публикация результатов13.04.2021

Кратко

This phase II trial studies how well combination chemotherapy and inotuzumab ozogamicin work in treating patients with B acute lymphoblastic leukemia. Drugs used in chemotherapy, such as cyclophosphamide, vincristine sulfate, doxorubicin hydrochloride, dexamethasone, methotrexate and cytarabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as inotuzumab ozogamicin, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving combination chemotherapy and inotuzumab ozogamicin may work better at treating B acute lymphoblastic leukemia.

Event-Free Survival

Start of treatment up to 2 years · Months

Treatment (Hyper-CVAD, Inotuzumab Ozogamicin)24 Months

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