Durvalumab and Tremelimumab in Treating Participants With Recurrent or Refractory Ovarian, Primary Peritoneal, or Fallopian Tube Cancer
| Заболевание | Platinum-Resistant Fallopian Tube Carcinoma, Platinum-Resistant Ovarian Carcinoma, Platinum-Resistant Primary Peritoneal Carcinoma, Recurrent Fallopian Tube Carcinoma |
|---|---|
| Фаза | Фаза 2 |
| Спонсор | M.D. Anderson Cancer Center |
| Статус | Завершено |
| Участники | 100 участн. |
| Вмешательство | Durvalumab, Tremelimumab |
| Дата начала | 18.05.2017 |
| Дата завершения | 11.09.2025 |
| Публикация результатов | 5.08.2026 |
Кратко
This phase II trial studies how well durvalumab and tremelimumab work in treating participants with ovarian, primary peritoneal, or fallopian tube cancer that has come back or does not respond to treatment. Immunotherapy with monoclonal antibodies, such as durvalumab and tremelimumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known whether give durvalumab and tremelimumab in combination or sequential administration works better in treating participants with ovarian, primary peritoneal, or fallopian tube cancer.
Immune-related Progression-free Survival (irPFS)
| Sequential Arm - High Grade Serous | 1.84 months |
|---|---|
| Combination Arm - High Grade Serous | 1.87 months |
| Sequential Arm - Clear Cell | 1.4 months |
| Combination Arm - Clear Cell | 2.32 months |
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