BENITIONSClinical Trial Intelligence

Pharmacokinetic, Safety, Tolerability and Immunogenicity Study of SB4 in Healthy Male Subjects

Фаза 1 Завершено NCT01865552

ЗаболеваниеHealthy
ФазаФаза 1
СпонсорSamsung Bioepis Co., Ltd.
СтатусЗавершено
Участники138 участн.
ВмешательствоSB4, EU sourced Enbrel, US sourced Enbrel
Дата начала05.2013
Дата завершения08.2013
Публикация результатов4.06.2019

Кратко

The purpose of this study is to compare the pharmacokinetics, safety and immunogenicity of SB4 and Enbrel (EU sourced Enbrel and US sourced Enbrel) in healthy male subjects.

Area Under the Concentration-time Curve From Time Zero to Infinity (AUCinf)

0 to 480 hours post-dose · µg·h/mL

SB4 in Part A769.069 ± 243.9039 µg·h/mL
EU Sourced Enbrel in Part A771.680 ± 226.2874 µg·h/mL
SB4 in Part B834.680 ± 242.7652 µg·h/mL
US Sourced Enbrel in Part B810.054 ± 195.9770 µg·h/mL
EU Sourced Enbrel in Part C790.110 ± 274.2535 µg·h/mL
US Sourced Enbrel in Part C768.228 ± 238.1251 µg·h/mL

Maximum Serum Concentration (Cmax)

0 to 480 hours post-dose · μg/mL

SB4 in Part A3.607 ± 1.4298 μg/mL
EU Sourced Enbrel in Part A3.435 ± 1.2390 μg/mL
SB4 in Part B3.869 ± 1.3251 μg/mL
US Sourced Enbrel in Part B3.613 ± 1.0252 μg/mL
EU Sourced Enbrel in Part C3.720 ± 1.5444 μg/mL
US Sourced Enbrel in Part C3.575 ± 1.4833 μg/mL

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