Androgen Deprivation Therapy Prior to Prostatectomy for Patients With Intermediate and High Risk Prostate Cancer
| Заболевание | Prostate Cancer, Prostatic Adenocarcinoma |
|---|---|
| Фаза | Не применимо |
| Спонсор | Memorial Sloan Kettering Cancer Center |
| Статус | Завершено |
| Участники | 41 участн. |
| Вмешательство | degarelix injection, degarelix injection, androgen deprivation therapy |
| Дата начала | 24.02.2012 |
| Дата завершения | 30.09.2024 |
| Публикация результатов | 29.07.2026 |
Кратко
Degarelix is an approved drug that is used to treat prostate cancer by lowering testosterone levels in the body. Degarelix is commonly given with radiation for prostate cancer, but less frequently with surgery since there has been no proven benefit with this approach. The investigators do not expect the patient to benefit directly from treatment with degarelix since their prostate will be removed shortly after the drug is given. Instead, the investigators hope to learn about how degarelix and other treatment that lowers your testosterone effects prostate cancer cells and use this information to develop better treatments in the future.
Percent Change in Prostate Cancer Cell Proliferation (Ki-67 Levels)
| Untreated Patients Degarelix Injection Occur at Days 4± 1 | 32 percent change |
|---|---|
| Untreated Patients Degarelix Injection Occur at Days and 7± 1. | 27 percent change |
| Untreated Patients With Androgen Deprivation | 88 percent change |
| Untreated Patients Degarelix Injection Occur at Days 14±1 | NA percent change |
Открыть в BENITIONS Открыть на ClinicalTrials.gov
Другие исследования по этому заболеванию
- A Study of Apalutamide (ARN-509) in Men With Non-Metastatic Castration-Resistant Prostate — Aragon Pharmaceuticals, Inc.
- Propranolol Hydrochloride in Treating Patients With Prostate Cancer Undergoing Surgery — Wake Forest University Health Sciences
- Testing the Safety of Different Doses of Olaparib Given Radium-223 for Men With Advanced P — National Cancer Institute (NCI)
- M6620 and Carboplatin With or Without Docetaxel in Treating Patients With Metastatic Castr — National Cancer Institute (NCI)
- A Study of Niraparib in Combination With Abiraterone Acetate and Prednisone Versus Abirate — Janssen Research & Development, LLC
- Testing Two Oral Drugs Combination (Cediranib and Olaparib) Compared to a Single Drug (Ola — National Cancer Institute (NCI)