BENITIONSClinical Trial Intelligence

Semaglutide Treatment, Appetite, and Eating Behavior: Long-term Effects

4상 완료 NCT05548647

대상 질환Obesity
임상 단계4상
스폰서University of Pennsylvania
상태완료
참여자 수120 명
중재(약물)Behavioral Treatment, Semaglutide 2.4 MG/0.75 ML Subcutaneous Solution [WEGOVY]
시작일2022년 7월 26일
완료일2025년 5월 12일
결과 공개일2026년 8월 3일

요약

This study will evaluate the effect of semaglutide on eating behavior, appetite (hunger/fullness), and food liking in the long-term, as compared to placebo. All participants will receive lifestyle modification (diet and exercise) counseling, and will be prescribed the FDA-approved weight loss medication, semaglutide, or placebo (an inactive saline solution) for 72 weeks.

Study 1 Ad Libitum Energy Intake (kcal) During a Buffet Lunch Meal (4 Hrs After Standardized Breakfast)

S1: Change from baseline to weeks 20, 40, and 60 · kcal

Behavioral Treatment + Placebo (Weeks 0-60)-75.1 ± 52.6 kcal
Behavioral Treatment + Medication (Weeks 0-60)-367.0 ± 37.2 kcal
Behavioral Treatment + Placebo (Weeks 0-60)-76.8 ± 73.8 kcal
Behavioral Treatment + Medication (Weeks 0-60)-317.0 ± 49.7 kcal
Behavioral Treatment + Placebo (Weeks 0-60)69.6 ± 73.9 kcal
Behavioral Treatment + Medication (Weeks 0-60)-200.0 ± 50.1 kcal
p-value<0.0001
Mean Difference (Net)291.9 (95% CI 164.0–419.8)

Study 2 Ad Libitum Energy Intake (kcal) During a Buffet Lunch Meal (4 Hrs After Standardized Breakfast)

S2: Endpoint comparison at week 72 · kcal

Continuous Placebo (Weeks 60-72)1073.0 ± 71.1 kcal
Medication (Semaglutide) Switched to Placebo (Weeks 60-72)951.8 ± 42.9 kcal
Continued Medication (Semaglutide) (Weeks 60-72)657.7 ± 81.5 kcal
p-value0.1513
Mean Difference (Final Values)121.2 (95% CI -46.0–288.4)

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