KEYMAKER-U01 Substudy 3: Efficacy and Safety Study of Pembrolizumab (MK-3475) When Used With Investigational Agents in Participants With Advanced Non-small Cell Lung Cancer (NSCLC), Previously Treated With Anti-programmed Cell Death Receptor Ligand 1 (PD-L1) Therapy (MK-3475-01C/KEYMAKER-U01C)
| 대상 질환 | Carcinoma, Non-Small-Cell Lung |
|---|---|
| 임상 단계 | 2상 |
| 스폰서 | Merck Sharp & Dohme LLC |
| 상태 | 완료 |
| 참여자 수 | 128 명 |
| 중재(약물) | Pembrolizumab, Boserolimab, MK-4830, diphenhydramine, acetaminophen |
| 시작일 | 2020년 1월 21일 |
| 완료일 | 2025년 4월 30일 |
| 결과 공개일 | 2026년 5월 13일 |
요약
The purpose of this study is to assess the efficacy and safety of pembrolizumab (MK-3475) in combination with boserolimab (MK-5890), MK-4830, MK-0482 in participants with advanced squamous or non-squamous NSCLC that have been previously treated with anti-PD-L1 therapy. This study is one of three pembrolizumab substudies being conducted under one pembrolizumab umbrella master protocol (MK-3475-U01/KEYMAKER-U01).
Objective Response Rate (ORR) According to Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1)
| Pembrolizumab + Boserolimab | 5.4 Percentage of participants |
|---|---|
| Pembrolizumab + MK-4830 | 11.1 Percentage of participants |
| Pembrolizumab + MK-0482 | 4.4 Percentage of participants |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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