Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations
| 대상 질환 | Advanced Malignant Solid Neoplasm, Glioblastoma, Recurrent Cholangiocarcinoma, Recurrent Glioma |
|---|---|
| 임상 단계 | 2상 |
| 스폰서 | National Cancer Institute (NCI) |
| 상태 | 진행 중(모집 완료) |
| 참여자 수 | 89 명 |
| 중재(약물) | Biopsy Procedure, Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging, Olaparib |
| 시작일 | 2019년 1월 30일 |
| 완료일 | 2025년 4월 2일 |
| 결과 공개일 | 2026년 6월 17일 |
요약
This phase II trial studies how well olaparib works in treating patients with glioma, cholangiocarcinoma, or solid tumors with IDH1 or IDH2 mutations that has spread from where it first started (primary site) to other places in the body (metastatic) and that does not respond to treatment (refractory). Olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.
Overall Response Rate
| Cohort 1A-Glioma Naïve to IDH I | 0 Participants |
|---|---|
| Cohort 1B- Glioma Pretreated | 0 Participants |
| Cohort 2A- Cholangio Naive | 0 Participants |
| Cohort 2B-Cholangio- Pretreated | 0 Participants |
| Cohort 3A Other -Naive | 0 Participants |
| Cohort 3B Other -Pretreated | 0 Participants |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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