Genetically Modified T-cells in Treating Patients With Recurrent or Refractory Malignant Glioma

1상 진행 중(모집 완료) NCT02208362

요약

This phase I trial studies the side effects and best dose of genetically modified T-cell immunotherapy in treating patients with malignant glioma that has come back (recurrent) or has not responded to therapy (refractory). A T cell is a type of immune cell that can recognize and kill abnormal cells in the body. T cells are taken from the patient's blood and a modified gene is placed into them in the laboratory and this may help them recognize and kill glioma cells. Genetically modified T-cells may also help the body build an immune response against the tumor cells.

Number of Participants With Grade 3 or Higher Toxicity Related to CAR T Cells

An average of 11 months · Participants

Number of Participants Experiencing a Dose Limiting Toxicity (DLT)

Up to 1 week following the last course, up to a total of 4 weeks (not including optional courses 4-6) · Participants

BENITIONS에서 보기 ClinicalTrials.gov 원문 보기

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• Phase II Study of BKM120 for Subjects With Recurrent Glioblastoma — L. Nicolas Gonzalez Castro, MD, PhD
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• Veliparib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed M — National Cancer Institute (NCI)

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