Cediranib Maleate and Olaparib Compared to Bevacizumab in Treating Patients With Recurrent Glioblastoma
| 대상 질환 | Recurrent Glioblastoma |
|---|---|
| 임상 단계 | 2상 |
| 스폰서 | National Cancer Institute (NCI) |
| 상태 | 진행 중(모집 완료) |
| 참여자 수 | 70 명 |
| 중재(약물) | Bevacizumab, Cediranib, Cediranib Maleate, Olaparib |
| 시작일 | 2017년 12월 7일 |
| 완료일 | 2022년 12월 31일 |
| 결과 공개일 | 2024년 2월 2일 |
요약
This randomized phase II trial studies how well cediranib maleate and olaparib work compared to bevacizumab in treating patients with glioblastoma that has come back (recurrent). Cediranib maleate and olaparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Immunotherapy with monoclonal antibodies, such as bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread.
Number of Participants With Progression-Free Survival at 6 Months
| Arm A (Olaparib, Cediranib Maleate) | 16 percentage of participants |
|---|---|
| Arm B (Bevacizumab) | 28 percentage of participants |
BENITIONS에서 보기 ClinicalTrials.gov 원문 보기
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