BENITIONSClinical Trial Intelligence

Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation

단계 해당 없음 완료 NCT01420393

대상 질환Heart Failure, Atrial Fibrillation
임상 단계단계 해당 없음
스폰서Ottawa Heart Institute Research Corporation
상태완료
참여자 수411 명
중재(약물)Rhythm control, Rate Control
시작일2011년 9월
완료일2021년 5월
결과 공개일2026년 5월 11일

요약

Atrial fibrillation and heart failure are two common heart conditions that are associated with an increase in death and suffering. When both of these two conditions occur in a patient the patient's prognosis is poor. These patients have poor life quality and are frequently admitted to the hospital. The treatment of atrial fibrillation in heart failure patients is extremely challenging. Two options for managing the atrial fibrillation are permitting the atrial fibrillation to continue but controlling the heart rate, or to convert the atrial fibrillation rhythm back to normal and try to maintain the heart in sinus rhythm. Until now, the method to keep the patient in normal sinus rhythm is with antiarrhythmic drugs. Studies using antiarrhythmic drugs to control the rhythm failed to show any survival benefit when compared with permitting the patient to be in atrial fibrillation. In the last few years, new development in techniques and technologies now enable catheter ablation (cauterization of tissue in the heart with a catheter) to be a successful treatment in abolishing atrial fibrillation and that this approach is better than antiarrhythmic drug to control the rhythm. However, there

Composite of All-cause Mortality and Heart Failure Events

Baseline to study completion, an average of 24 months · Participants

Rhythm Control50 Participants
Rate Control64 Participants

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