BENITIONSClinical Trial Intelligence

Using the Cholinergic Anti-Inflammatory Pathway to Treat Systemic Lupus Musculoskeletal Pain

該当なし 完了 NCT02822989

対象疾患Lupus Erythematosus, Systemic, Musculoskeletal Pain
該当なし
スポンサーNorthwell Health
ステータス完了
参加者数19 名
介入(薬剤)Vagus nerve stimulation, Sham vagus nerve stimulation
開始日2017年11月1日
完了日2018年4月30日
結果公開日2026年7月8日

概要

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune, inflammatory disease and musculoskeletal pain is one of the most common symptoms. This study will investigate whether transcutaneous stimulation of the vagus nerve will decrease lupus musculoskeletal pain. This study will additionally investigate the biologic effects of vagus nerve stimulation on inflammation. It will be the first clinical study using one of the body's own pathways of modulating the immune system and inflammatory response, the cholinergic anti-inflammatory pathway, in SLE.

Change in Musculoskeletal Pain From Baseline.

5 days · units on a scale

Vagus Nerve Stimulation-5.00 units on a scale
Sham Vagus Nerve Stimulation0.10 units on a scale

Percentage of Subjects With Treatment Emergent Adverse Events.

12 days · Participants

Vagus Nerve Stimulation1 Participants
Sham Vagus Nerve Stimulation0.00 Participants

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