BENITIONSClinical Trial Intelligence

Lenalidomide in Treating Patients With Multiple Myeloma Undergoing Autologous Stem Cell Transplant

第3相 実施中(募集終了) NCT00114101

対象疾患DS Stage I Multiple Myeloma, DS Stage II Multiple Myeloma, DS Stage III Multiple Myeloma, Refractory Multiple Myeloma
第3相
スポンサーNational Cancer Institute (NCI)
ステータス実施中(募集終了)
参加者数460 名
介入(薬剤)Autologous Hematopoietic Stem Cell Transplantation, Laboratory Biomarker Analysis, Lenalidomide, Melphalan, Peripheral Blood Stem Cell Transplantation
開始日2004年12月15日
完了日2012年12月31日
結果公開日2013年7月1日

概要

This randomized phase III trial studies lenalidomide to see how well it works compared to a placebo in treating patients with multiple myeloma who are undergoing autologous stem cell transplant. Giving chemotherapy before a peripheral blood stem cell transplant helps kill any cancer cells that are in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow. After treatment, stem cells are collected from the patient's blood and stored. More chemotherapy is then given to prepare the bone marrow for the stem cell transplant. The stem cells are then returned to the patient to replace the blood-forming cells that were destroyed by the chemotherapy. Biological therapies, such as lenalidomide, may stimulate or suppress the immune system in different ways and stop cancer cells from growing. Giving lenalidomide after autologous stem cell transplant may be an effective treatment for multiple myeloma.

Time to Progression

Duration of study (up to 10years) · months

Lenalidomide Maintenance39 months
Placebo Maintenance21 months
p-value<0.001
Hazard Ratio (HR)0.36 (95% CI 0.26–0.53)

BENITIONS で見る ClinicalTrials.gov の原文を見る

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このページは ClinicalTrials.gov の公開データをまとめたものです。医学的助言ではなく、投資助言でもありません。必ず専門医にご相談ください。