Effect of PDE5 Inhibition on Adipose Metabolism in Humans

2期 已完成 NCT04684589

摘要

This is a randomized, double-blinded, placebo-controlled study of the effects of PDE5 inhibition with tadalafil on adipose tissue in obese individuals. Adipose metabolism will be measured using magnetic resonance imaging (MRI) scans and by aspirating a small amount of adipose to measure gene expression.

Thermoneutral FSF of WAT at the Level of the Umbilicus at 12 Weeks.

12 weeks · % of voxel

Thermoneutral Subcutaneous Adipose Tissue Expression of UCP1 (Normalized Expression Units) at 12 Weeks.

12 weeks · normalized expression units

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