BENITIONSClinical Trial Intelligence

Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia

Phase 2 Active, not recruiting NCT00070499

ConditionChronic Myeloid Leukemia, BCR-ABL1 Positive
PhasePhase 2
SponsorNational Cancer Institute (NCI)
StatusActive, not recruiting
Enrollment406 participants
InterventionsDasatinib, Imatinib Mesylate, Laboratory Biomarker Analysis
Start dateAug 15, 2004
Completion dateNov 1, 2010
Results postedJul 10, 2012

Summary

This randomized phase IIB trial studies imatinib mesylate at two different doses and dasatinib to see how well they work in treating patients with previously untreated chronic phase chronic myelogenous leukemia. Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

Molecular Response Rate at 12 Months

pretreatment and after 12 months of treatment · participants

Standard Dose Imatinib A5 participants
High Dose Imatinib14 participants
Dasatinib27 participants
Standard Dose Imatinib B18 participants
p-value0.073

Open in BENITIONS View on ClinicalTrials.gov

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