Imatinib Mesylate or Dasatinib in Treating Patients With Previously Untreated Chronic Phase Chronic Myelogenous Leukemia
Phase 2
Active, not recruiting
NCT00070499
| Condition | Chronic Myeloid Leukemia, BCR-ABL1 Positive |
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| Phase | Phase 2 |
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| Sponsor | National Cancer Institute (NCI) |
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| Status | Active, not recruiting |
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| Enrollment | 406 participants |
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| Interventions | Dasatinib, Imatinib Mesylate, Laboratory Biomarker Analysis |
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| Start date | Aug 15, 2004 |
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| Completion date | Nov 1, 2010 |
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| Results posted | Jul 10, 2012 |
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Summary
This randomized phase IIB trial studies imatinib mesylate at two different doses and dasatinib to see how well they work in treating patients with previously untreated chronic phase chronic myelogenous leukemia. Imatinib mesylate or dasatinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.
Molecular Response Rate at 12 Months
pretreatment and after 12 months of treatment · participants
| Standard Dose Imatinib A | 5 participants |
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| High Dose Imatinib | 14 participants |
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| Dasatinib | 27 participants |
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| Standard Dose Imatinib B | 18 participants |
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Open in BENITIONS
View on ClinicalTrials.gov
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