Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy
| Заболевание | Cytokine Release Syndrome, ICANS, Lymphoma, Non-Hodgkin, Multiple Myeloma |
|---|---|
| Фаза | Фаза 2 |
| Спонсор | University of Alabama at Birmingham |
| Статус | Завершено |
| Участники | 20 участн. |
| Вмешательство | Siltuximab |
| Дата начала | 15.11.2021 |
| Дата завершения | 20.01.2026 |
| Публикация результатов | 3.06.2026 |
Кратко
This study will evaluate the use of siltuximab to decrease the severity of cytokine release syndrome (CRS) and immune effector cell-associated neurological syndrome (ICANS) in patients who will receive chimeric antigen receptor (CAR) T-cell therapy for the treatment of hematological malignancies.
Participants With a Complete Response for Cytokine Release Syndrome (CRS)
| Siltuximab | 15 Participants |
|---|
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