BENITIONSClinical Trial Intelligence

Blinatumomab in Treating Younger Patients With Relapsed B-cell Acute Lymphoblastic Leukemia

3상 진행 중(모집 완료) NCT02101853

대상 질환Recurrent B Acute Lymphoblastic Leukemia
임상 단계3상
스폰서National Cancer Institute (NCI)
상태진행 중(모집 완료)
참여자 수669 명
중재(약물)Allogeneic Hematopoietic Stem Cell Transplantation, Asparaginase, Blinatumomab, Cyclophosphamide, Cytarabine
시작일2014년 12월 17일
완료일2021년 6월 30일
결과 공개일2022년 12월 6일

요약

This randomized phase III trial studies how well blinatumomab works compared with standard combination chemotherapy in treating patients with B-cell acute lymphoblastic leukemia that has returned after a period of improvement (relapsed). Immunotherapy with blinatumomab may allow the body's immune system to attack and destroy some types of leukemia cells. It is not yet known whether blinatumomab is more effective than standard combination chemotherapy in treating relapsed B-cell acute lymphoblastic leukemia.

Disease Free Survival (DFS) of High-risk (HR) and Intermediate-risk (IR) Relapse Patients

Up to 2 years from date of randomization · percentage of participants

Arm A (HR and IR Control)39.04 percentage of participants
Arm B (HR and IR Blinatumomab)54.44 percentage of participants

Disease Free Survival (DFS) of Low Risk (LR) Relapse Patients

Up to 3 years from date of randomization · percentage of participants

Arm C (LR Control)58.94 percentage of participants
Arm D (LR Blinatumomab)67.00 percentage of participants

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