BENITIONSClinical Trial Intelligence

Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery

第2相 完了 NCT01708941

対象疾患Recurrent Melanoma, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7
第2相
スポンサーNational Cancer Institute (NCI)
ステータス完了
参加者数88 名
介入(薬剤)Ipilimumab, Laboratory Biomarker Analysis, Recombinant Interferon Alfa-2b
開始日2013年3月25日
完了日2017年8月8日
結果公開日2019年1月11日

概要

This randomized phase II trial studies how well ipilimumab with or without high-dose recombinant interferon alpha-2b works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab, may block tumor growth by targeting certain cells. Recombinant interferon alfa-2b may interfere with the growth of tumor cells. It is not yet known whether ipilimumab is more effective with or without high-dose recombinant interferon alfa-2b in treating melanoma.

Progression-free Survival (PFS)

Assessed every 3 months for two years, then every 6 months for 3 years, then every 12 months for up to 10 years · months

Ipilimumab + HDI7.5 months
Ipilimumab Alone4.4 months
p-value0.490

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