Ipilimumab With or Without High-Dose Recombinant Interferon Alfa-2b in Treating Patients With Stage III-IV Melanoma That Cannot Be Removed by Surgery
第2相
完了
NCT01708941
| 対象疾患 | Recurrent Melanoma, Stage IIIA Cutaneous Melanoma AJCC v7, Stage IIIB Cutaneous Melanoma AJCC v7, Stage IIIC Cutaneous Melanoma AJCC v7 |
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| 相 | 第2相 |
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| スポンサー | National Cancer Institute (NCI) |
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| ステータス | 完了 |
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| 参加者数 | 88 名 |
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| 介入(薬剤) | Ipilimumab, Laboratory Biomarker Analysis, Recombinant Interferon Alfa-2b |
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| 開始日 | 2013年3月25日 |
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| 完了日 | 2017年8月8日 |
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| 結果公開日 | 2019年1月11日 |
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概要
This randomized phase II trial studies how well ipilimumab with or without high-dose recombinant interferon alpha-2b works in treating patients with stage III-IV melanoma that cannot be removed by surgery. Monoclonal antibodies, such as ipilimumab, may block tumor growth by targeting certain cells. Recombinant interferon alfa-2b may interfere with the growth of tumor cells. It is not yet known whether ipilimumab is more effective with or without high-dose recombinant interferon alfa-2b in treating melanoma.
Progression-free Survival (PFS)
Assessed every 3 months for two years, then every 6 months for 3 years, then every 12 months for up to 10 years · months
| Ipilimumab + HDI | 7.5 months |
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| Ipilimumab Alone | 4.4 months |
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